Fritz-Laylin, Lillian K. and Prochnik, Simon E. and Ginger, Michael L. and Dacks, Joel B. and Carpenter, Meredith L. and Field, Mark C. and Kuo, Alan and Paredez, Alex and Chapman, Jarrod and Pham, Jonathan and Shu, Shengqiang and Neupane, Rochak and Cipriano, Michael and Mancuso, Joel and Tu, Hank and Salamov, Asaf and Lindquist, Erika and Shapiro, Harris and Lucas, Susan and Grigoriev, Igor V. and Cande, W. Z. and Fulton, C. and Rokhsar, D. S. and Dawson, Scott C. (2010) The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell, 140 (5). pp. 631-642. ISSN 0092-8674Full text not available from this repository.
Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living amoeboflagellate Naegleria gruberi belongs to a varied and ubiquitous protist clade (Heterolobosea) that diverged from other eukaryotic lineages over a billion years ago. Analysis of the 15,727 protein-coding genes encoded by Naegleria's 41 Mb nuclear genome indicates a capacity for both aerobic respiration and anaerobic metabolism with concomitant hydrogen production, with fundamental implications for the evolution of organelle metabolism. The Naegleria genome facilitates substantially broader phylogenomic comparisons of free-living eukaryotes than previously possible, allowing us to identify thousands of genes likely present in the pan-eukaryotic ancestor, with 40% likely eukaryotic inventions. Moreover, we construct a comprehensive catalog of amoeboid-motility genes. The Naegleria genome, analyzed in the context of other protists, reveals a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal, sexual, signaling, and metabolic modules.
|Journal or Publication Title:||Cell|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited By:||Dr Michael Ginger|
|Deposited On:||14 Dec 2010 14:51|
|Last Modified:||29 Nov 2015 01:02|
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