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Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science.

Skeldon, K. D. and Gibson, G. M. and Wyse, C. A. and McMillan, L. C. and Monk, S. D. and Longbottom, C. and Padgett, M. J. (2005) Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science. Applied Optics, 44 (22). pp. 4712-4721.

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Abstract

We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity >= 70 ppt and response time from >= 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential. (c) 2005 Optical Society of America.

Item Type: Article
Journal or Publication Title: Applied Optics
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Science and Technology > Engineering
ID Code: 34822
Deposited By: Dr Stephen Monk
Deposited On: 09 Dec 2010 10:20
Refereed?: Yes
Published?: Published
Last Modified: 24 Jan 2014 05:18
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/34822

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