Rudd, Timothy R. and Skidmore, Mark A. and Guimond, Scott E. and Holman, Joseph and Turnbull, Jeremy E. and Lauder, Robert M. and Fernig, David G. and Yates, Edwin A. (2009) The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and haemostasis, 102 (5). pp. 874-878. ISSN 0340-6245
The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
Actions (login required)