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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids.

Rudd, Timothy R. and Skidmore, Mark A. and Guimond, Scott E. and Holman, Joseph and Turnbull, Jeremy E. and Lauder, Robert M. and Fernig, David G. and Yates, Edwin A. (2009) The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and haemostasis, 102 (5). pp. 874-878. ISSN 0340-6245

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    Abstract

    The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.

    Item Type: Article
    Journal or Publication Title: Thrombosis and haemostasis
    Subjects: R Medicine > R Medicine (General)
    Departments:
    ID Code: 34800
    Deposited By: Dr Bob Lauder
    Deposited On: 08 Dec 2010 14:55
    Refereed?: Yes
    Published?: Published
    Last Modified: 23 Jul 2014 14:52
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/34800

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