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Flagellum function and assembly during the Leishmania life cycle.

Gluenz, Eva and Ginger, Michael L. and McKean, Paul G. (2010) Flagellum function and assembly during the Leishmania life cycle. Current Opinion in Microbiology, 13 (4). pp. 473-479. ISSN 1369-5274

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Abstract

During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages.

Item Type: Article
Journal or Publication Title: Current Opinion in Microbiology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 34497
Deposited By: Dr Paul G McKean
Deposited On: 12 Nov 2010 14:37
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:38
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/34497

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