Titman, Andrew C. and Lancaster, Gillian A. and Carmichael, Katie and Scutt, Diane (2011) Accounting for bias due to a non-ignorable tracing mechanism in a retrospective breast cancer cohort study. Statistics in Medicine, 30 (4). pp. 324-334. ISSN 1097-0258Full text not available from this repository.
We consider the analysis of competing risks in a retrospective breast cancer cohort study where tracing of patients is dependent on survival to a pre-specified truncation time. We demonstrate that if ignored the observed cause-specific hazards will become distorted before the truncation time. Two approaches to account for the tracing bias are considered. Firstly, a likelihood based method using piecewise constant transition intensities under a Markov assumption. Secondly, a pseudo-likelihood method using inverse probability of tracing weights. For the breast cancer example, both methods improve the precision of estimates compared to a conventional approach based on excluding patients.
|Journal or Publication Title:||Statistics in Medicine|
|Uncontrolled Keywords:||multi-state model ; tracing bias ; breast cancer ; pseudo-likelihood|
|Subjects:||Q Science > QA Mathematics|
|Departments:||Faculty of Science and Technology > Mathematics and Statistics|
|Deposited By:||Dr Andrew Titman|
|Deposited On:||23 Sep 2010 08:50|
|Last Modified:||07 Jan 2015 15:38|
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