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Estimation of pharmacokinetic parameters with the R package PK.

Jaki, Thomas and Wolfsegger, Martin J. (2011) Estimation of pharmacokinetic parameters with the R package PK. Pharmaceutical Statistics, 10 (2). pp. 284-288. ISSN 1539-1604

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Abstract

The study of the pharmacokinetic (PK) behavior of a compound is crucial to understand the absorbtion, distribution, metabolism and elimination of a drug by the body. PK studies involve measuring the concentration of the drug in the plasma or blood at several time points post drug administration. The classic complete data design samples each subject at all predefined time points. Ethical considerations and restrictions in blood volume, however, lead to incomplete data designs being frequently used instead. In serial sampling designs only one sample is taken from each subject, whereas batch designs take samples more than once from each subject, but not at all time points. In this manuscript the R package PK, which enables the computation of various PK parameters in complete and incomplete data designs, is introduced and some examples are given.

Item Type: Article
Journal or Publication Title: Pharmaceutical Statistics
Uncontrolled Keywords: AUC ; bioequivalence ; pharmacokinetics ; PK ; R ; toxicology
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 33521
Deposited By: Dr Thomas Jaki
Deposited On: 01 Jun 2010 11:19
Refereed?: Yes
Published?: Published
Last Modified: 09 Oct 2013 14:50
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/33521

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