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A mosaic cell layer in human pregnancy.

Byrne, S. and Challis, E. and Williams, J. L. R. and Pringle, J. H. and Hennessy, J. M. and Ockleford, Colin D. (2010) A mosaic cell layer in human pregnancy. Placenta, 31 (5). pp. 373-379. ISSN 0143-4004

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Abstract

We present evidence for a novel histological and embryological relationship at the human materno-fetal interface. Here an epi- endo- thelium forms an integrated unicellular layer lining the intervillus space in between the anchoring villi that attach the placenta to the uterus. This layer appears to be derived from two different germ layers (mesoderm and ectoderm). The data presented here reveals that when a probe for the Y-chromosome is used to test the gender of placental cells following the birth of male or female babies, the cell-sheet is a genetic mosaic derived from two individuals (mother and baby). The endothelium is maternally derived; the epithelium is fetal derived. This new allo- epi- endothelium model is relevant to theories of germ layer separation in development, reproductive immunology and the endocrinology of implantation and placentation. It demonstrates cooperative intercellular interactions that are fundamental to achieving a major goal of human interstitial implantation the establishment of a blood sinus for haematotrophic nutrition. Poor implantation is a fundamental cause of pregnancy pathology and this knowledge will be useful in development of our understanding of pregnancy diseases.

Item Type: Article
Journal or Publication Title: Placenta
Uncontrolled Keywords: Germ layers ; Placenta ; Pregnancy ; Basal plate ; Extra-embryonic membranes ; Materno-fetal interaction
Subjects: R Medicine > R Medicine (General)
Departments:
ID Code: 33277
Deposited By: Mr Richard Ingham
Deposited On: 10 May 2010 11:18
Refereed?: Yes
Published?: Published
Last Modified: 23 Jul 2014 14:51
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/33277

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