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Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care.

Mannix, Kathryn and Ahmedzai, Sam Hjelmeland and Anderson, Heather and Bennett, Michael I. and Lloyd-Williams, Mari and Wilcock, Andrew (2000) Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care. Palliative Medicine, 14 (6). pp. 455-461.

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Abstract

This work was undertaken by the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland (APM) as a demonstration project in developing clinical guidelines relevant to palliative care from a pragmatic approach to literature review and grading of clinical evidence. CANCERLIT and Embase were searched for relevant papers written in English, published since 1980. Each study identified was rated against agreed criteria for levels of evidence. Most studies were not specifically designed to define speed of response, and were not undertaken in palliative care patients. Thus, careful reading and grading of each study was necessary. Sufficient evidence was identified to make recommendations for clinical practice in a palliative care population of patients, and areas for future research have been identified. Bisphosphonates appear to have a role in managing pain from metastases which has been refractory to conventional analgesic management and where oncological or orthopaedic intervention is delayed or inappropriate.

Item Type: Article
Journal or Publication Title: Palliative Medicine
Uncontrolled Keywords: pain relief • bone metastases • bisphosphonates • clinical guidelines
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 32199
Deposited By: Mrs Yaling Zhang
Deposited On: 12 Mar 2010 09:04
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:07
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/32199

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