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Feasibility study of transcutaneous electrical nerve stimulation (TENS) for cancer bone pain.

Bennett, Michael I. and Johnson, Mark I. and Brown, Sarah and Radford, Helen and Brown, Julia M. and Searle, Robert D. (2010) Feasibility study of transcutaneous electrical nerve stimulation (TENS) for cancer bone pain. Journal of Pain, 11 (4). pp. 351-359. ISSN 1526-5900

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Abstract

This multicenter study assessed the feasibility of conducting a phase III trial of transcutaneous electrical nerve stimulation (TENS) in patients with cancer bone pain recruited from palliative care services. Eligible patients received active and placebo TENS for 1 hour at site of pain in a randomized crossover design; median interval between applications 3 days. Responses assessed at 30 and 60 minutes included numerical and verbal ratings of pain at rest and on movement, and pain relief. Recruitment, tolerability, adverse events, and effectiveness of blinding were also evaluated. Twenty-four patients were randomised and 19 completed both applications. The intervention was well tolerated. Five patients withdrew: 3 due to deteriorating performance status, and 2 due to increased pain (1 each following active and placebo TENS). Confidence interval estimation around the differences in outcomes between active and placebo TENS suggests that TENS has the potential to decrease pain on movement more than pain on rest. Nine patients did not consider that a placebo was used; the remaining 10 correctly identified placebo TENS. Feasibility studies are important in palliative care prior to undertaking clinical trials. Our findings suggest that further work is required on recruitment strategies and refining the control arm before evaluating TENS in cancer bone pain.

Item Type: Article
Journal or Publication Title: Journal of Pain
Uncontrolled Keywords: Transcutaneous electric nerve stimulation (TENS) ; pain ; cancer of bone ; randomized controlled trial ; palliative care
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 32153
Deposited By: Mr Richard Ingham
Deposited On: 11 Mar 2010 09:33
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:06
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/32153

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