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Factors influencing constipation in advanced cancer patients: a prospective study of opioid dose, dantron dose and physical functioning.

Bennett, Michael I. and Cresswell, Helen (2003) Factors influencing constipation in advanced cancer patients: a prospective study of opioid dose, dantron dose and physical functioning. Palliative Medicine, 17 (5). pp. 418-422.

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Abstract

The relationship between opioid dose, dantron dose, bowel function and physical functioning (measured with the modified Barthel Index) was determined in a sample of 50 inpatients with advanced cancer. Data were collected prospectively from chart review and patient interviews one week after admission to allow for protocol-driven management of constipation to be established. Bowel scores were significantly reduced in 35 patients treated with opioids compared with 15 patients not treated with opioids. Within the opioid group, however, there was no relationship between opioid dose, bowel score, dantron dose or Barthel Index. Higher doses of dantron were associated with better physical functioning (but not opioid dose) suggesting that for any given dose of opioid, fitter patients were treated with larger doses of laxatives. Factors other than opioid dose and physical functioning may be more important in contributing to constipation in this group of patients. Less potent opioid drugs, such as codeine, are just as likely to cause constipation as more potent opioids.

Item Type: Article
Journal or Publication Title: Palliative Medicine
Uncontrolled Keywords: constipation • dantron • modi"ed Barthel Index • opioid drugs
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 32141
Deposited By: Mrs Yaling Zhang
Deposited On: 10 Mar 2010 15:11
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:06
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/32141

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