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Gabapentin in the treatment of neuropathic pain.

Bennett, Michael I. and Simpson, Karen H. (2004) Gabapentin in the treatment of neuropathic pain. Palliative Medicine, 18 (1). pp. 5-11.

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Abstract

This paper reviews the pharmacology and clinical effectiveness of gabapentin in the treatment of neuropathic pain. Gabapentin has antihyperalgesic and antiallodynic properties but does not have significant actions as an anti-nociceptive agent. Its mechanisms of action appear to be a complex synergy between increased GABA synthesis, non-NMDA receptor antagonism and binding to the 2 subunit of voltage dependent calcium channels. The latter action inhibits the release of excitatory neurotransmitters. Clinically, several large randomized controlled trials have demonstrated its effectiveness in the treatment of a variety of neuropathic pain syndromes. Patients with neuropathic pain can expect a mean reduction in pain score of 2.05 points on an 11 point numerical rating scale compared with a reduction of 0.94 points if they had taken the placebo. Around 30% of patients can expect to achieve more than 50% pain relief and a similar number will also experience minor adverse events; the most common of which are somnolence and dizziness. In patients with neuropathic pain due to cancer, higher response rates might be observed with gabapentin when administered with opioids because of a synergistic interaction.

Item Type: Article
Journal or Publication Title: Palliative Medicine
Uncontrolled Keywords: Gabapentin • neuropathic pain
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 32140
Deposited By: Mrs Yaling Zhang
Deposited On: 10 Mar 2010 14:45
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:06
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/32140

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