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Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine.

Jones, Steven H. and Hemsley,, D. and Ball,, S. and Serra, A. (1997) Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine. Behavioural Brain Research, 88 (1). pp. 103-114.

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Abstract

The Kamin blocking effect (KBE) is an established animal learning paradigm measuring selective processing, in which reduced blocking reflects allocation of greater processing resources to non-relevant information. Two KBE tasks are described below. Results from studies using the first (between-subjects) task indicate that KBE is abolished in acute schizophrenics with positive psychotic symptoms. It is also abolished in the relatives of schizophrenic subjects, although interpretation of this finding is hampered by poor performance of subjects in the control condition. The second (within-subjects) task indicated abolition of KBE in schizophrenic patients with positive psychotic symptoms. Administration of acute amphetamine to normal human subjects did not significantly disrupt performance on the first task. Whilst for the second task, although blocking was limited to placebo subjects, overall pre-exposure effects are not sufficiently strong to indicate specific drug effects.

Item Type: Article
Journal or Publication Title: Behavioural Brain Research
Uncontrolled Keywords: Schizophrenia ; Associative learning ; Amphetamine ; Blocking ; Animal models
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 31919
Deposited By: Mrs Yaling Zhang
Deposited On: 26 Feb 2010 10:29
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:03
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/31919

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