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London-East Anglia randomised controlled trial of cognitive-behavioural therapy for psychosis. II: Predictors of outcome.

Garety, P. and Fowler, D. and Kuipers, E. and Freeman, D. and Dunn, G. and Bebbington, P. and Hadley, C. and Jones, Steven H. (1997) London-East Anglia randomised controlled trial of cognitive-behavioural therapy for psychosis. II: Predictors of outcome. The British Journal of Psychiatry, 171 (5). pp. 420-426. ISSN 1472-1465

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Abstract

BACKGROUND: Despite growing evidence of the effectiveness of cognitive- behavioural therapy (CBT) for psychosis, typically only about 50% of patients show a positive response to treatment. This paper reports the first comprehensive investigation of factors which predict treatment outcome. METHOD: In a randomised controlled trial of CBT for medication- resistant psychosis (see Part I) measures were taken at baseline of demographic, clinical and cognitive variables. Changes over time were assessed on the Brief Psychiatric Rating Scale and the relationship between potential predictor variables and outcome was investigated using analysis of variance and covariance. RESULTS: A number of baseline variables were identified as predictors of good outcome in the CBT group. Key predictors were a response indicating cognitive flexibility concerning delusions (P = 0.005) and the number of recent admissions (P = 0.002). Outcome was less predictable in the control group and was not predicted by any cognitive variable. CONCLUSIONS: Good outcome is strongly predicted in patients with persistent delusions by a cognitive measure, while this was not the case in controls. Thus we argue that positive outcome in CBT is due in part to specific effects on delusional thinking.

Item Type: Article
Journal or Publication Title: The British Journal of Psychiatry
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 31917
Deposited By: Mrs Yaling Zhang
Deposited On: 26 Feb 2010 10:05
Refereed?: Yes
Published?: Published
Last Modified: 17 Sep 2013 08:20
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/31917

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