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Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia: A 1231-iomazenil SPET study.

Ball, Suzanne and Busatto, Geraldo F. and David, Anthony S. and Jones, Steven H. and Hemsley, David R. and Pilowsky, Lynn S. and Costa, Durval C. and Ell, Peter J. and Kerwin, Robert W. (1998) Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia: A 1231-iomazenil SPET study. Biological Psychiatry, 43 (2). pp. 107-117. ISSN 1873-2402

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Abstract

Background: The role of the inhibitory neurotransmitter gamma aminobutyric acid (GABA) in schizophrenia has previously been investigated using postmortem material. Recently, using single photon emission tomography (SPET) with the selective benzodiazepine antagonist 123I-lomazenil as the radioligand, we have demonstrated an in vivo relationship between reduced GABAA/benzodiazepine receptor binding and the severity of positive symptomatology in schizophrenia. The present study aimed to build on this using the same in vivo scanning techniques, and relating findings to cognitive functioning. Methods: Ten nonpsychiatric control subjects and 15 schizophrenic patients, matched for age and handedness, were scanned. A battery of neuropsychologic tests was also administered. Results: Correlational analysis revealed a pattern of increased correlations between GABAA/benzodiazepine receptor binding and task performance, in the schizophrenic group compared to the control group. Conclusions: Findings are preliminary but suggest a relationship between reduced GABAA/benzodiazepine receptor binding and poorer cognitive functioning, involving memory and visual attention processes, in the schizophrenic group but not in the control group. A role for GABA in the pathophysiology of schizophrenia is suggested. Limitations of the present study and suggestions for future research are discussed.

Item Type: Article
Journal or Publication Title: Biological Psychiatry
Uncontrolled Keywords: GABA ; schizophrenia ; neuropsychology ; SPET ; lomazenil ; benzodiazepine receptor
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Health Research
ID Code: 31916
Deposited By: Mrs Yaling Zhang
Deposited On: 26 Feb 2010 09:51
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:03
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/31916

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