Jones, Steven H. and Gray, Jeffrey A. and Hemsley, David R. (1992) Loss of the Kamin blocking effect in acute but not chronic schizophrenics. Biological Psychiatry, 32 (9). pp. 739-755. ISSN 1873-2402Full text not available from this repository.
Differences between research diagnostic criteria (RDC)-diagnosed acute and chronic schizophrenics and normal controls were studied using a Kamin blocking procedure. Blocking is an established animal learning procedure, thought by some researchers to reflect selective attention; decreased blocking indicates increased processing of irrelevant stimuli. It was predicted that this pattern would be obtained in acute schizophrenics, tested soon after admission, for two reasons: (1) evidence from previous clinical studies indicates that acute schizophrenics are more aware of nonsalient aspects of their environment than controls; and (2) blocking is disrupted in animals in a hyperdopaminergic state and restored by neuroleptic medication. This was the case: acute, but not chronic, schizophrenics showed disrupted blocking. This disruption was especially clear in those acute schizophrenics tested within 2 weeks of hospital admission. By the second test session (in a cross-over design), there was some evidence of normalization in performance in the acute schizophrenics. These findings are considered with regard to the dopamine hypothesis of schizophrenia.
|Journal or Publication Title:||Biological Psychiatry|
|Subjects:||R Medicine > R Medicine (General)|
|Departments:||Faculty of Health and Medicine > Health Research|
|Deposited By:||Mr Richard Ingham|
|Deposited On:||25 Feb 2010 10:09|
|Last Modified:||26 Jul 2012 17:02|
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