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Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation.

Duncan, Callum and Li, Hong and Dykhuizen, Roelf and Frazer, Rennie and Johnston, Peter and MacKnight, Gillian and Smith, Lorna and Lamza, Kathryn and McKenzie, Hamish and Batt, Les and Kelly, Denise and Golden, Michael and Benjamin, Nigel and Leifert, Carlo (1997) Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. Comparative Biochemistry and Physiology Part A: Physiology, 118 (4). pp. 939-948.

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Abstract

Over the last 20 years, dietary nitrate has been implicated in the formation of methemoglobin and carcinogenic nitrosamines in humans. This has led to restrictions of nitrate and nitrite levels in food and drinking water. However, there is no epidemiological evidence for an increased risk of gastric and intestinal cancer in population groups with high dietary vegetable or nitrate intake. A reevaluation of our currently very negative perception of dietary nitrates comes from recent research into the metabolism and enterosalivary circulation of nitrate in mammals. These studies showed that nitrate is converted to nitrite in the oral cavity that then “fuels” an important mammalian resistance mechanism against infectious diseases. Moreover, there is now evidence that the conversion of nitrate into oxides of nitrogen prevents the formation carcinogenic nitrosamines.

Item Type: Article
Journal or Publication Title: Comparative Biochemistry and Physiology Part A: Physiology
Uncontrolled Keywords: Diet ; gastric cancer ; gastroenteritis ; methemoglobinemia ; nitrate ; nitrite ; nitric oxide ; N-nitroso compounds
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: UNSPECIFIED
ID Code: 31625
Deposited By: Mrs Yaling Zhang
Deposited On: 28 Jan 2010 12:09
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 16:59
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/31625

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