Clark, J. and Merson, S. and Jhavar, S. and Flohr, P. and Edwards, S. and Foster, C. S. and Eeles, R. and Martin, Frank L. and Phillips, D. H. and Crundwell, M. and Christmas, T. and Thompson, A. and Fisher, C. and Kovacs, G. and Cooper, C. S. (2007) Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene, 26 (18). pp. 2667-2673. ISSN 0950-9232Full text not available from this repository.
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.
|Journal or Publication Title:||Oncogene|
|Uncontrolled Keywords:||prostate cancer ; ERG gene ; TMPRSS2 gene ; ERG fusion transcripts|
|Subjects:||G Geography. Anthropology. Recreation > GE Environmental Sciences|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
Faculty of Health and Medicine > Health Research
Faculty of Arts & Social Sciences > Politics & International Relations (Merged into PPR 2010-08-01)
|Deposited By:||Mr Richard Ingham|
|Deposited On:||14 Jan 2010 10:59|
|Last Modified:||26 Jul 2012 16:56|
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