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Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.

Clark, J. and Merson, S. and Jhavar, S. and Flohr, P. and Edwards, S. and Foster, C. S. and Eeles, R. and Martin, Frank L. and Phillips, D. H. and Crundwell, M. and Christmas, T. and Thompson, A. and Fisher, C. and Kovacs, G. and Cooper, C. S. (2007) Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene, 26 (18). pp. 2667-2673. ISSN 0950-9232

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Abstract

TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.

Item Type: Article
Journal or Publication Title: Oncogene
Uncontrolled Keywords: prostate cancer ; ERG gene ; TMPRSS2 gene ; ERG fusion transcripts
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 31375
Deposited By: Mr Richard Ingham
Deposited On: 14 Jan 2010 10:59
Refereed?: Yes
Published?: Published
Last Modified: 31 Jan 2014 10:32
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/31375

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