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Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.

Noel, E. E. and Ragavan, N. and Walsh, Michael J. and James, S. Y. and Matanhelia, S. S. and Nicholson, C. M. and Lu, Y.-J. and Martin, Frank L. (2008) Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland. Prostate Cancer and Prostatic Diseases, 11 (2). pp. 173-180. ISSN 1365-7852

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Abstract

Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.

Item Type: Article
Journal or Publication Title: Prostate Cancer and Prostatic Diseases
Uncontrolled Keywords: differential expression ; oligonucleotide microarrays ; prostate adenocarcinoma ; peripheral zone ; quantitative real-time RT-PCR ; transition zone
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 31371
Deposited By: Mr Richard Ingham
Deposited On: 14 Jan 2010 09:28
Refereed?: Yes
Published?: Published
Last Modified: 06 Sep 2013 19:51
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/31371

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