Lancaster EPrints

Risk of prostate cancer after isolated high-grade prostatic intraepithelial neoplasia (HGPIN) detected on extended core needle biopsy : a UK hospital experience.

Singh, Paras B. and Nicholson, Caroline M. and Ragavan, Narasimhan and Blades, Rosemary A. and Martin, Frank L. and Matanhelia, Shyam S. (2009) Risk of prostate cancer after isolated high-grade prostatic intraepithelial neoplasia (HGPIN) detected on extended core needle biopsy : a UK hospital experience. BMC Urology, 9 (3). ISSN 1471-2490

[img]
Preview
PDF (1471-2490-9-3.pdf)
Download (240Kb) | Preview

    Abstract

    Background High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor lesion to prostate cancer (CaP). UK-based studies examining the occurrence of isolated HGPIN and subsequent risk of CaP are lacking. Our aim was to assess the occurrence of HGPIN in a regional UK population and to determine whether in a retrievable cohort of such patients that had repeat extended core biopsies, there was an elevated risk of CaP. Methods A retrospective analysis of the pathology database was conducted at our institution (Lancashire Teaching Hospitals NHS Foundation Trust) for prostate biopsies recorded between January 2001 and December 2005 (all extended core biopsies). Those patients with isolated HGPIN on 1st set of biopsies were identified and, their clinical characteristics and pathological findings from subsequent biopsies (if any) were determined. The risk of CaP on subsequent biopsies based on presenting baseline PSA was stratified. Results Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 CaP diagnoses were made. Age at first biopsy (P < 0.001), higher mean baseline prostate-specific antigen (PSA) (P < 0.005) and higher mean change in PSA (P < 0.05) were predictive of CaP detection on repeat biopsies. PSA ranges and their associated predictive values for cancer were: 0 to 5 ng/ml – 11%; 5 to 10 ng/ml – 34%; 10 to 20 ng/ml – 50%; and > 20 ng/ml – 87.5%. Conclusion Based on our results, we recommend delaying the 1st repeat biopsy at low PSA range but to have a shorter interval to repeat biopsies at intermediate and higher PSA ranges.

    Item Type: Article
    Journal or Publication Title: BMC Urology
    Additional Information: © 2009 Singh et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
    Departments: Faculty of Science and Technology > Lancaster Environment Centre
    ID Code: 31354
    Deposited By: Mr Richard Ingham
    Deposited On: 13 Jan 2010 10:26
    Refereed?: Yes
    Published?: Published
    Last Modified: 09 Apr 2014 20:31
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/31354

    Actions (login required)

    View Item