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Regulation of Arabidopsis 14-3-3 gene expression by GABA.

Lancien, Muriel and Roberts, Michael R (2006) Regulation of Arabidopsis 14-3-3 gene expression by GABA. Plant, Cell and Environment, 29 (7). pp. 1430-1436. ISSN 0140-7791

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    Abstract

    The function in plants of the non-protein amino acid, gamma-aminobutyric acid (GABA) is poorly understood. In this study, we show that GABA down-regulates the expression of a large sub-set of 14-3-3 gene family members in Arabidopsis thaliana seedlings in a calcium, ethylene and abscisic acid-dependent manner. Gene expression is not affected when seedlings are supplied with glutamate, a precursor of GABA. The repression of 14-3-3 gene expression by GABA is dependent on functional ethylene and abscisic acid signalling pathways, since the response is lost in the etr1-1, abi1-1 and abi2-1 mutants. Calcium measurements show that in contrast to glutamate, GABA does not elicit a cytoplasmic calcium elevation, suggesting that the GABA response is unlikely to be mediated by glutamate receptors, as has been suggested previously. We suggest that in addition to its role as a stress-related metabolite, GABA may regulate gene expression in Arabidopsis, including members of the 14-3-3 gene family.

    Item Type: Article
    Journal or Publication Title: Plant, Cell and Environment
    Additional Information: The definitive version is available at www.blackwell-synergy.com (c) Blackwell 2006.
    Uncontrolled Keywords: 14-3-3 protein GABA Arabidopsis thaliana plant stress
    Subjects: Q Science > QH Natural history > QH301 Biology
    Departments: Faculty of Science and Technology > Lancaster Environment Centre
    ID Code: 288
    Deposited By: Dr Michael R Roberts
    Deposited On: 05 Jan 2007
    Refereed?: Yes
    Published?: Published
    Last Modified: 06 Sep 2013 19:40
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/288

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