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Cuticle preparations from Necator americanus and their immunogenicity in the infected host.

Pritchard, David Idris and McKean, Paul G. and Rogan, Michael Thomas (1988) Cuticle preparations from Necator americanus and their immunogenicity in the infected host. Molecular and Biochemical Parasitology, 28 (3). pp. 275-283. ISSN 0166-6851

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Abstract

Cuticle samples have been prepared from the human parasitic nematode Necator americanus using detergent solubilisation with sodium dodecyl sulphate and subsequent reduction of disulphide bonds using 2-beta-mercaptoethanol. It would appear that N. americanus, like many other nematodes, relies on relatively small collagenous proteins, linked by disulphide bonds, to maintain the integrity of its cuticle. These molecules are normally hidden from the immune system during the course of infection but are potentially immunogenic. It is suggested that waves of antibodies, firstly with specificity against superficial cuticular epitopes followed by antibodies against deeper lying, structural elements, should be induced during vaccination to effectively destroy the nematode at the cuticular level.

Item Type: Article
Journal or Publication Title: Molecular and Biochemical Parasitology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 26071
Deposited By: Dr Paul G McKean
Deposited On: 09 Mar 2009 16:43
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 16:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/26071

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