McKean, Paul G. and Pritchard, D. I. (1989) The action of a mast cell protease on the cuticular collagens of Necator americanus. Parasite Immunology, 11 (3). pp. 293-297. ISSN 1365-3024Full text not available from this repository.
Collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult Necator americanus and shown to be susceptible to digestion by purified mast cell proteases. Although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important underlying layers open to immune attack.
|Journal or Publication Title:||Parasite Immunology|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited By:||Dr Paul G McKean|
|Deposited On:||09 Mar 2009 16:34|
|Last Modified:||13 Sep 2016 01:08|
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