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The action of a mast cell protease on the cuticular collagens of Necator americanus.

McKean, Paul G. and Pritchard, D. I. (1989) The action of a mast cell protease on the cuticular collagens of Necator americanus. Parasite Immunology, 11 (3). pp. 293-297.

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Abstract

Collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult Necator americanus and shown to be susceptible to digestion by purified mast cell proteases. Although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important underlying layers open to immune attack.

Item Type: Article
Journal or Publication Title: Parasite Immunology
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 26067
Deposited By: Dr Paul G McKean
Deposited On: 09 Mar 2009 16:34
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 16:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/26067

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