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The identification of a species-specific antigen from Necator americanus.

Pritchard, D. I. and McKean, Paul G. and Rogan, M. T. and Schad, G. A. (1990) The identification of a species-specific antigen from Necator americanus. Parasite Immunology, 12 (3). pp. 259-267.

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Abstract

A 17 kD protein of Necator americanus was isolated by SDS-PAGE and used to raise monospecific antisera in rabbits. ELISA and Western blotting against a range of parasite extracts demonstrated the species specificity of this protein. It is expressed at all stages of the life-cycle, appears to be accumulated through the larval stages to adulthood, and can be localized in the oesophageal glands and cuticle of the adult parasite. The possible nature and diagnostic potential of this protein is discussed.

Item Type: Article
Journal or Publication Title: Parasite Immunology
Uncontrolled Keywords: hookworm • diagnosis • antigen • ELISA • Western blotting • SDS-PAGE • colloidal gold • electron microscopy
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 26063
Deposited By: Dr Paul G McKean
Deposited On: 12 Mar 2009 10:22
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 16:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/26063

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