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Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.

O’Dea, Kieran P. and McKean, Paul G. and Harris, Alan and Brown, K. Neil (1995) Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro. Molecular and Biochemical Parasitology, 72 (1-2). pp. 111-119. ISSN 0166-6851

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Abstract

Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.

Item Type: Article
Journal or Publication Title: Molecular and Biochemical Parasitology
Uncontrolled Keywords: Plasmodium chabaudi chabaudi ; Plasmodium falciparum ; Malaria ; Merozoite surface protein 1 ; Processing
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
Faculty of Arts & Social Sciences > Linguistics & English Language
ID Code: 26053
Deposited By: Dr Paul G McKean
Deposited On: 12 Mar 2009 09:55
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 16:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/26053

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