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The sequential analysis of repeated binary responses: a score test for the case of three time points.

Sooriyarachchi, Marina Roshini and Whitehead, John and Whitehead, Anne and Bolland, Kim (2006) The sequential analysis of repeated binary responses: a score test for the case of three time points. Statistics in Medicine, 25 (13). pp. 2196-2214.

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Abstract

In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.

Item Type: Article
Journal or Publication Title: Statistics in Medicine
Additional Information: RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research
Uncontrolled Keywords: binary data • longitudinal data • repeated observations • score test • sequential clinical trial
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 2476
Deposited By: ep_importer
Deposited On: 01 Apr 2008 13:11
Refereed?: Yes
Published?: Published
Last Modified: 09 Oct 2013 14:49
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/2476

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