Whitehead, John and Bollard, Kim and Matsushita, Tatsuru and Sooriyarachchi, Marina Roshini and Whitehead, Anne (2003) Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods. Biometrics, 59 (3). pp. 701-709. ISSN 1541-0420Full text not available from this repository.
In a sequential clinical trial, accrual of data on patients often continues after the stopping criterion for the study has been met. This is termed "overrunning." Overrunning occurs mainly when the primary response from each patient is measured after some extended observation period. The objective of this article is to compare two methods of allowing for overrunning. In particular, simulation studies are reported that assess the two procedures in terms of how well they maintain the intended type I error rate. The effect on power resulting from the incorporation of "overrunning data" using the two procedures is evaluated.
|Journal or Publication Title:||Biometrics|
|Additional Information:||RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research|
|Subjects:||Q Science > QA Mathematics|
|Departments:||Faculty of Science and Technology > Mathematics and Statistics|
|Deposited On:||29 Mar 2008 12:25|
|Last Modified:||07 Jan 2015 13:54|
Actions (login required)