Pettitt, Anthony and Forrester, M. and Gibson, G. (2007) Bayesian inference of hospital-acquired infections and control measures given imperfect surveillance data. Biostatistics, 8 (2). pp. 383-401. ISSN 1468-4357Full text not available from this repository.
This paper describes a stochastic epidemic model developed to infer transmission rates of asymptomatic communicable pathogens within a hospital ward. Inference is complicated by partial observation of the epidemic process and dependencies within the data. The epidemic process of nosocomial communicable pathogens can be partially observed by routine swabs testing for the presence of the pathogen. False-negative swab results must be accounted for and make it difficult to ascertain the number of patients who were colonized. Reversible jump Markov chain Monte Carlo methods are used within a Bayesian framework to make inferences about the colonization rates and unknown colonization times. The methods are applied to routinely collected data concerning methicillin-resistant Staphylococcus Aureus in an intensive care unit to estimate the effectiveness of isolation on reducing transmission of the bacterium.
|Journal or Publication Title:||Biostatistics|
|Additional Information:||RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research|
|Uncontrolled Keywords:||Bayesian inference ; False negatives ; Imperfect detectability ; Infectious diseases ; Markov chain Monte Carlo methods ; MRSA ; Reversible jump methods ; Screening ; Sensitivity ; Staphylococcus ; Stochastic epidemic models|
|Subjects:||Q Science > QA Mathematics|
|Departments:||Faculty of Science and Technology > Mathematics and Statistics|
Faculty of Science and Technology > Lancaster Environment Centre
|Deposited On:||29 Mar 2008 12:17|
|Last Modified:||07 Jan 2015 13:54|
Actions (login required)