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Maximum likelihood estimation of coalesce times in genealogical trees.

Meligkotsidou, Loukia and Fearnhead, Paul (2005) Maximum likelihood estimation of coalesce times in genealogical trees. Genetics, 171 (4). pp. 2073-2084.

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Abstract

We develop a method for maximum-likelihood estimation of coalescence times in genealogical trees, based on population genetics data. For this purpose, a Viterbi-type algorithm is constructed to maximize the joint likelihood of the coalescence times. Marginal confidence intervals for the coalescence times based on the profile likelihoods are also computed. Our method of finding MLEs and calculating C.I.'s appears to be more accurate than alternative numerical maximization methods, and maximum-likelihood inference appears to be more accurate than other existing model-free approaches to estimating coalescent times. We demonstrate the method on two different data sets: human Y chromosome DNA data and fungus DNA data

Item Type: Article
Journal or Publication Title: Genetics
Additional Information: RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 2431
Deposited By: ep_importer
Deposited On: 31 Mar 2008 09:44
Refereed?: Yes
Published?: Published
Last Modified: 09 Oct 2013 15:41
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/2431

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