Chetwynd, Amanda G. and Diggle, Peter J. and Sousa, Ines (2005) Exploratory analysis of longitudinal trials with staggered intervention times. Biostatistics, 6 (3). pp. 479-485. ISSN 1468-4357
Full text not available from this repository.Abstract
Longitudinal trials involving surgical interventions commonly have subject-specific intervention times, due to constraints on the availability of surgeons and operating theatres. Moreover, the intervention often effects a discontinuous change in the mean response. We propose a nonparametric estimator for the mean response profile of longitudinal data with staggered intervention times and a discontinuity at the times of intervention, as an exploratory tool to assist the formulation of a suitable parametric model. We use an adaptation of the standard generalized additive model algorithm for estimation, with smoothing constants chosen by a cross-validation criterion. We illustrate the method using longitudinal data from a trial to assess the effect of lung resection surgery in the treatment of emphysema patients.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Biostatistics |
| Additional Information: | RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research |
| Uncontrolled Keywords: | Back-fitting algorithm ; Cross-validation ; Exploratory analysis ; Longitudinal trials ; Lung resection surgery ; Nonparametric estimator |
| Subjects: | Q Science > QA Mathematics |
| Departments: | Faculty of Science and Technology > Mathematics and Statistics VC's Office Faculty of Health and Medicine > Medicine Faculty of Science and Technology > Lancaster Environment Centre |
| ID Code: | 2408 |
| Deposited By: | ep_importer |
| Deposited On: | 31 Mar 2008 16:35 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 16:21 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/2408 |
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