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Role of transdermal potential difference during intophoretic drug delivery.

Bandrivskyy, Andriy and Bernjak, Alan and McClintock, Peter V. E. (2004) Role of transdermal potential difference during intophoretic drug delivery. IEEE Transactions on Bio-Medical Engineering, 51 (9). pp. 1683-1685. ISSN 0018-9294

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    Abstract

    Potential differences have been measured during transdermal iontophoresis in order to establish the effect of voltage, as opposed to current, on cutaneous blood flow. It is known that, even in the absence of drugs, the iontophoresis current can sometimes produce increased blood flow. The role of voltage in this process is studied through single-ended measurements (between electrode and body) of the potential difference during iontophoresis with 100-/spl mu/A, 20-s current pulses through deionized water, saturated 20.4% NaCl solution, 1 % acetylcholine, and 1 % sodium nitroprusside. It is found that the voltage needed to deliver the current varied by orders of magnitudes less than the differences in the conductance of these different electrolytes, and it is concluded that, at least for the present current protocol, the voltage as such is not an important factor in increasing the blood flow.

    Item Type: Article
    Journal or Publication Title: IEEE Transactions on Bio-Medical Engineering
    Additional Information: "©2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE." "This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder."
    Subjects: Q Science > QC Physics
    Departments: Faculty of Science and Technology > Physics
    ID Code: 23855
    Deposited By: ep_ss_importer
    Deposited On: 20 Feb 2009 16:25
    Refereed?: Yes
    Published?: Published
    Last Modified: 26 Jul 2012 16:15
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/23855

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