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Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.

Masters, A. K. and Huddart, H. and Hetherington, A. M. (1994) Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle. General Pharmacology, 25 (3). pp. 481-486.

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Abstract

1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.

Item Type: Article
Journal or Publication Title: General Pharmacology
Uncontrolled Keywords: Abscisic acic ; BAY K8644 ; calcium contractures ; K-depolarization ; nifedipine
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: Faculty of Science and Technology > Engineering
ID Code: 22484
Deposited By: ep_ss_importer
Deposited On: 29 Jan 2009 10:31
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 16:01
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/22484

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