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The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue.

Taylor, C. A. M. and Coates, David and Shirras, Alan D. (1996) The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue. Gene, 181 (1-2). pp. 191-197.

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Abstract

Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only has one, which is identical to the C-terminal domain of sACE. We have sequenced 2452 bases of a 3.1-kb mRNA whose predicted translation product shows 40% identity with mammalian testicular ACE, and 48% identity with an already identified Drosophila homologue of ACE (Ance). We have termed this gene Acer (Angiotensin converting enzyme-related). Acer mRNA is found in the developing dorsal vessel (heart) during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods, independently of the duplication which gave rise to the two domain somatic ACE of mammals.

Item Type: Article
Journal or Publication Title: Gene
Uncontrolled Keywords: Dipeptidyl dipeptidase ; Metalloproteinase ; Dna sequencing ; Gene duplication ; Zn2+-Binding motif ; Heart
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 22182
Deposited By: ep_ss_importer
Deposited On: 13 Feb 2009 09:53
Refereed?: Yes
Published?: Published
Last Modified: 29 Nov 2012 13:33
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/22182

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