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Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells.

Nunez, M. I. and McMillan, T. J. and Valenzuela, M. T. and Ruiz de Almodovar, J. M. and Pedraza, V. (1996) Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology, 39 (2). pp. 155-165.

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Abstract

The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at biologically relevant doses. In this review we present new data and summarize the role of the DNA double-strand breaks (dsb) induced by ionizing radiation and DNA dsb rejoining as determinants of cellular radiosensitivity. When cells were irradiated at high dose-rate, two molecular end-points were identified which often correlated with radiosensitivity: (1) the apparent number of DNA dsb induced per Gy per DNA unit and (2) the half-time of the fast component of the DNA dsb rejoining kinetics. These two molecular determinants, not mutually exclusive, may be linked through a common factor such as the conformation of DNA.

Item Type: Article
Journal or Publication Title: Radiotherapy and Oncology
Uncontrolled Keywords: Author Keywords ; Radiosensitivity ; DNA double-strand breaks ; Initial damage ; Rejoining
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Departments: Faculty of Science and Technology > Lancaster Environment Centre
VC's Office
ID Code: 22144
Deposited By: ep_ss_importer
Deposited On: 13 Feb 2009 16:08
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:56
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/22144

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