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Estimation of Spatial Variation in Risk Using Matched Case-control Data.

Jarner, Mikala F. and Diggle, Peter J. and Chetwynd, Amanda G. (2002) Estimation of Spatial Variation in Risk Using Matched Case-control Data. Biometrical Journal, 44 (8). pp. 936-945. ISSN 1521-4036

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Abstract

A common problem in environmental epidemiology is to estimate spatial variation in disease risk after accounting for known risk factors. In this paper we consider this problem in the context of matched case-control studies. We extend the generalised additive model approach of Kelsall and Diggle (1998) to studies in which each case has been individually matched to a set of controls. We discuss a method for fitting this model to data, apply the method to a matched study on perinatal death in the North West Thames region of England and explain why, if spatial variation is of particular scientific interest, matching is undesirable.

Item Type: Article
Journal or Publication Title: Biometrical Journal
Uncontrolled Keywords: Spatial variation in risk • Generalised additive models • Epidemiology • Matched case-control design
Subjects: Q Science > QA Mathematics
Departments: Faculty of Health and Medicine > Health Research
Faculty of Health and Medicine > Medicine
VC's Office
Faculty of Science and Technology > Mathematics and Statistics
ID Code: 20942
Deposited By: Prof Amanda Chetwynd
Deposited On: 04 Dec 2008 15:18
Refereed?: No
Published?: Published
Last Modified: 26 Jul 2012 15:42
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/20942

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