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Immunohistochemical localization of androgen receptors in the urogenital tracts of human embryos.

Sajjad, Yasmin and Quenby, Siobhan and Nickson, Paul and Lewis-Jones, D. Iwan and Vince, Gill S. (2004) Immunohistochemical localization of androgen receptors in the urogenital tracts of human embryos. Reproduction, 128 (3). pp. 331-339.

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Abstract

The aim of this study was to investigate androgen receptor (AR) expression in the developing human urogenital tract. The distribution of AR was examined in paraffin-embedded tissue sections of the lower urogenital tract using 55 human embryos of 8–12 weeks of gestation. Immunohistochemistry was performed for AR detection and gender was determined by polymerized chain reaction. There were no differences in the distribution of AR in male and female embryos at any stage of gestation. AR was present only in the mesenchymal tissues of the urogenital sinus at 8 weeks whilst the epithelium was negative, but after 9 weeks the epithelium also showed progressively more positive staining. In the phallus, AR staining was prominent. There was far less staining in the epithelium of the urethral groove from 8 to 10 weeks, whilst the mesenchyme of the urethral folds showed positive staining. At 11 and 12 weeks, both the urethral groove and folds showed uniform staining. The genital tubercle, genital swelling and bulbourethral gland precusors were also positively stained, although paramesonephric ducts were negative. Staining was observed in the mesonephric duct from 9 weeks. There was an absence of staining in the rectum at all stages of gestation. The expression of AR in an epithelium may be dependent upon the mesenchyme. Mesenchymal–epithelial interactions played an important role in development, as has been described in experimental animals. AR expression could play a part in the growth of the genital organs.

Item Type: Article
Journal or Publication Title: Reproduction
Additional Information: RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Medicine
ID Code: 2015
Deposited By: ep_importer
Deposited On: 05 Feb 2010 11:35
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:37
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/2015

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