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Healthy and pre-eclamptic placental basal plate lining cells:quantitative comparisons based on confocal laser scanning microscopy

Smith, R K and Ockleford, C D and Byrne, S and Bosio, P and Sanders, R (2004) Healthy and pre-eclamptic placental basal plate lining cells:quantitative comparisons based on confocal laser scanning microscopy. Microscopy Research and Technique, 64 (1). pp. 54-62. ISSN 1059-910X

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Abstract

Immunocytochemical confocal laser scanning microscope images of the monolayer of cells lining the intervillus space at the basal plate of term placentae were analysed using stereology. Immunoreactively-distinct regions of this mosaic layer were measured. In basal plate from healthy pregnancies, trophoblast epithelium occupied 18.91% of the surface area and endothelium 60.81%. In pre-eclampsia the equivalent areas were 15.57% and 67.63%. Acellular fibrinoid covers the remaining area and this component decreases in area in pre-eclampsia. The statistically significant increase in the cellular endothelial compartment may be relevant to the hypertensive pathology of pre-eclampsia as endothelial signalling plays a major role in regulation of blood pressure. (C) 2004 Wiley-Liss, Inc.

Item Type: Article
Journal or Publication Title: Microscopy Research and Technique
Additional Information: RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies
Uncontrolled Keywords: pre-eclampsia • basal plate • intervillus space • caveolin-1 • endothelial cells • trophoblast invasion • cytokeratin expression • placental development
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Medicine
ID Code: 1999
Deposited By: ep_importer
Deposited On: 05 Feb 2010 10:28
Refereed?: Yes
Published?: Published
Last Modified: 27 Oct 2014 16:40
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/1999

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