Smith, R K and Ockleford, C D and Byrne, S and Bosio, P and Sanders, R (2004) Healthy and pre-eclamptic placental basal plate lining cells: Quantitative comparisons based on confocal laser scanning microscopy. Microscopy Research Techniques, 64 (1). pp. 54-62. ISSN 1059-910XFull text not available from this repository.
Immunocytochemical confocal laser scanning microscope images of the monolayer of cells lining the intervillus space at the basal plate of term placentae were analysed using stereology. Immunoreactively-distinct regions of this mosaic layer were measured. In basal plate from healthy pregnancies, trophoblast epithelium occupied 18.91% of the surface area and endothelium 60.81%. In pre-eclampsia the equivalent areas were 15.57% and 67.63%. Acellular fibrinoid covers the remaining area and this component decreases in area in pre-eclampsia. The statistically significant increase in the cellular endothelial compartment may be relevant to the hypertensive pathology of pre-eclampsia as endothelial signalling plays a major role in regulation of blood pressure. (C) 2004 Wiley-Liss, Inc.
|Journal or Publication Title:||Microscopy Research Techniques|
|Additional Information:||RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies|
|Uncontrolled Keywords:||pre-eclampsia • basal plate • intervillus space • caveolin-1 • endothelial cells • trophoblast invasion • cytokeratin expression • placental development|
|Subjects:||R Medicine > R Medicine (General)|
|Departments:||Faculty of Health and Medicine > Medicine|
|Deposited On:||05 Feb 2010 10:28|
|Last Modified:||26 Jul 2012 15:36|
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