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Immunocytochemical localization of a caveolin-1 isoform in human term extra-embryonic membranes using confocal laser scanning microscopy:Implications for the complexity of the materno-fetal junction

Byrne, S and Cheent, A and Dimond, J and Fisher, G and Ockleford, C D (2001) Immunocytochemical localization of a caveolin-1 isoform in human term extra-embryonic membranes using confocal laser scanning microscopy:Implications for the complexity of the materno-fetal junction. Placenta, 22 (6). pp. 499-510. ISSN 0143-4004

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Abstract

This immunochemical, immunocytochemical, histological and ultrastructural study demonstrates the presence of caveolin 1 in a number of locations in term human extra-embryonic membranes. Strong expression was observed in fetal blood vessel endothelial cells of chorionic villi (cv) and in cv, amniotic and chorionic plate mesenchymal cells, but weak expression was characteristic of trophoblast. Expression in the amniotic epithelium indicated a stronger association with apical as opposed to base-lateral membranes. Strong immunoreactivity in the thin lining layer of the maternal blood space of the basal plate was a surprising finding. Previously defined as trophoblast, we argue that this is at least partly endothelium based on this new histological, ultrastructural and immunocytochemical data. (C) 2001 Harcourt Publishers Ltd.

Item Type: Article
Journal or Publication Title: Placenta
Additional Information: RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies
Uncontrolled Keywords: VASCULAR ENDOTHELIAL-CELLS ; TARGETED DOWN-REGULATION ; NITRIC-OXIDE SYNTHASE ; NUCLEAR TRANSLOCATION ; TRANSPORT VESICLES ; PROSTATE-CANCER ; SKELETAL-MUSCLE ; GENE FAMILY ; EXPRESSION ; PROTEIN
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Medicine
ID Code: 1997
Deposited By: ep_importer
Deposited On: 05 Feb 2010 11:24
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:36
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/1997

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