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Reactions to other corticosteroids in patients with positive patch test reactions to budesonide.

Wilkinson, S. M. and Hollis, S. and Beck, M. H. (1995) Reactions to other corticosteroids in patients with positive patch test reactions to budesonide. Journal of the American Academy of Dermatology, 33 (6). pp. 963-968.

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Abstract

Background: Corticosteroid cross-reactions have been classified into four well-defined groups. A previous study of patch test reactions to other corticosteroids in patients allergic to hydrocortisone failed to conform to these groups. It was suggested that substitution at the C6 and C9 positions of the corticosteroid was the most important determinant of a further reaction. Objective: Our aim was to analyze multiple positive patch tests to corticosteroids in patients sensitized to budesonide to confirm our earlier findings. Methods: Forty-six patients with positive patch tests to budesonide were patch-tested to 17 other topical corticosteroids. The results were examined by a generalized linear model and a chi-square test. Results: Substitution of the corticosteroid at the C6 and C9 positions significantly reduced the number of reactions. A different substitution at the C16 and C17 positions was less important, and that at the C21 position was of no significance. Conclusion: Patients sensitized to budesonide are most likely to react to other non-C6 and non-C9 substituted corticosteroids.

Item Type: Article
Journal or Publication Title: Journal of the American Academy of Dermatology
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Engineering
ID Code: 19600
Deposited By: ep_ss_importer
Deposited On: 13 Nov 2008 09:46
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:33
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19600

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