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Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systematic sclerosis.

Anderson, M. E. and Hollis, S. and Moore, T. and Jayson, M. I. V. and Herrick, A. L. (1996) Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systematic sclerosis. British Journal of Rheumatology, 35 (12). pp. 1281-1288.

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Abstract

We have non-invasively assessed neurovascular control mechanisms in forearm skin of 10 healthy control subjects, eight patients with primary Raynaud's phenomenon (PRP) and 10 patients with systemic sclerosis (SSc) by iontophoresing acetylcholine (endothelial dependent), sodium nitroprusside (endothelial independent) and adrenaline, and measuring subsequent blood flow responses by dual-channel laser Doppler. Because basal forearm blood flow is low, adrenaline response was assessed by attenuation of reperfusion hyperaemia following 60 s of upper arm occlusion. Reperfusion hyperaemia prior to adrenaline iontophoresis differed significantly between groups (F2.21, = 4.3, P = 0.03), being lowest in the SSc and highest in the PRP group. However, the degree of attenuation of this hyperaemia by adrenaline did not differ between groups and all groups demonstrated similar vasodilatory responses to acetylcholine and to sodium nitroprusside. These findings may reflect that abnormalities in vascular tone in patients with Raynaud's phenomenon are local to the digits, or that vasoactive agents not examined in this study play a key role.

Item Type: Article
Journal or Publication Title: British Journal of Rheumatology
Uncontrolled Keywords: Iontophoresis ; Laser Doppler ; Primary Raynaud's phenomenon ; Systemic sclerosis ; Scleroderma ; Neuroendothelial control
Subjects: Q Science > QA Mathematics
Departments: UNSPECIFIED
ID Code: 19520
Deposited By: ep_ss_importer
Deposited On: 14 Nov 2008 11:18
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:31
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19520

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