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Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus?

Shaw, J. E. and Gokal, R. and Hollis, Sally and Boulton, A. J. M. (1998) Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus? Diabetes Research and Clincal Practice, 39 (1). pp. 55-61. ISSN 0168-8227

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Abstract

In patients with Type 1 diabetes mellitus complicated by diabetic nephropathy and retinopathy, it is usually believed that significant neuropathy is almost universal, but few studies have directly addressed this. This study assessed neuropathy in 91 such subjects, using vibration perception thresholds (VPT) and the neuropathy disability score (NDS). A total of 34% of subjects had no neuropathy on age adjusted VPT (z score) and 26% had no neuropathy on NDS. The severity of neuropathy as measured by VPT z score was related to increasing glycated haemoglobin (P=0.02) and male sex (P=0.03), and NDS was independently associated with age (P<0.0001) and HbA1c (P=0.003). These factors together accounted for only 12 and 31% of the total variance in VPT z score and NDS, respectively. In conclusion, the study has shown that a significant proportion of patients with diabetic nephropathy are free of neuropathy, but the full explanation for their protection from neuropathy is unclear.

Item Type: Article
Journal or Publication Title: Diabetes Research and Clincal Practice
Uncontrolled Keywords: Diabetic neuropathy ; Diabetic nephropathy ; Diabetes mellitus ; Renal transplantation
Subjects: Q Science > QA Mathematics
Departments: UNSPECIFIED
ID Code: 19476
Deposited By: ep_ss_importer
Deposited On: 12 Nov 2008 14:53
Refereed?: Yes
Published?: Published
Last Modified: 30 Oct 2013 09:13
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19476

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