Lancaster EPrints

The assessment of therapeutic response of oropharyngeal and oesophageal candidiasis in AIDS using a new scoring system: studies with D0870.

Hood, Stephen V. and Hollis, Sally and Percy, Meryl and Atkinson, Gill and Williams, Keith and Denning, David W. (1999) The assessment of therapeutic response of oropharyngeal and oesophageal candidiasis in AIDS using a new scoring system: studies with D0870. Clinical Infectious Diseases, 28 (3). pp. 587-596. ISSN 1537-6591

[img]
Preview
PDF (515149.pdf)
Download (232Kb) | Preview

    Abstract

    We developed and compared five scoring systems designed to quantitate therapeutic response in cases of oropharyngeal candidiasis. We utilized prospectively collected data on 114 patients treated with several doses of the azole D0870. Patients were infected with fluconazole-susceptible (n = 49) or-resistant organisms (MIC, ≥16 mg/mL; n = 61). Patients with fluconazole resistance had lower CD4+ cell counts at baseline; more symptoms (P = .0006); a higher frequency of dysgeusia (P = .004), dysphagia (P = .006), and throat pain (P = .0034); and greater oral coverage by plaques of Candida. There was no difference between the two groups in terms of colony-forming units, and any change did not correlate with response to therapy. Resolution of dysphagia (P < .01) and oral pain (P < .01) correlated well with response to therapy, unlike retrosternal pain and throat pain, which were also less frequent. Xerostomia, a “furry” taste, and dysgeusia were frequent nonspecific symptoms. Scoring system C, weighting resolution of a symptom higher than absence of a symptom at baseline, yielded the best correlation with global outcome (r = 0.86) and allows the quantitation of incomplete but clinically beneficial responses to therapy.

    Item Type: Article
    Journal or Publication Title: Clinical Infectious Diseases
    Additional Information: Copyright © 1999. University of Chicago Press.
    Subjects: Q Science > QA Mathematics
    Departments: UNSPECIFIED
    ID Code: 19419
    Deposited By: ep_ss_importer
    Deposited On: 18 Nov 2008 16:29
    Refereed?: Yes
    Published?: Published
    Last Modified: 26 Jul 2012 15:29
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/19419

    Actions (login required)

    View Item