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Ankle-brachial pressure index in systemic sclerosis: influence of disease sub-type and anticentromere antibody.

Wan, M. C. and Moore, T. and Hollis, Sally and Herrick, A. L. (2001) Ankle-brachial pressure index in systemic sclerosis: influence of disease sub-type and anticentromere antibody. Rheumatology, 40 (10). pp. 1102-1105.

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Abstract

Objective. To test the hypothesis that patients with limited cutaneous systemic sclerosis (SSc) have a higher incidence of lower limb large vessel disease than patients with diffuse cutaneous disease, and that anticentromere antibody is a risk factor for lower limb large vessel disease. Methods. Clinical and laboratory data from 119 patients with SSc (91 patients with limited cutaneous disease, 28 patients with diffuse cutaneous disease) who had bilateral ankle brachial pressure indices (ABPI) measured between March 1997 and January 2000 were reviewed retrospectively. Results. There was no evidence of reduced ABPI in limited cutaneous disease (P=0.65), average reduction 0.01 [95% confidence interval (CI) -0.04 to +0.07]. There was some suggestion of reduced ABPI in anticentromere-positive patients (P=0.12), average reduction 0.04 (95% CI -0.01 to +0.09). Conclusions. The severity of large vessel macrovascular disease, as assessed by ABPI, is not dependent on disease subtype. Anticentromere antibody may be weakly associated with a reduction in ABPI.

Item Type: Article
Journal or Publication Title: Rheumatology
Uncontrolled Keywords: Ankle brachial pressure index ; Systemic sclerosis ; Anticentromere antibody.
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 19325
Deposited By: ep_ss_importer
Deposited On: 18 Nov 2008 13:20
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19325

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