Friede, T. and Miller, F. and Bischoff, W. and Kieser, M. (2001) A note on change point estimation in dose-response trials. Computational Statistics and Data Analysis, 37 (2). pp. 219-232.Full text not available from this repository.
An often used model for the shape of a drug's dose–response relationship is the following: the curve increases to a certain dose until a plateau is reached. In this situation, the minimum dose with maximum effect can be seen as a change point in a regression model. We present four estimators for the change point and compare their performance with respect to selection rates and loss function based criteria by extensive simulations. The choice of the loss function depending on the practical situation is discussed. Application of the estimators is illustrated by an example.
|Journal or Publication Title:||Computational Statistics and Data Analysis|
|Uncontrolled Keywords:||Change point estimator ; Dose–response relationship ; Loss function ; LINEX loss|
|Subjects:||Q Science > QA Mathematics|
|Departments:||Faculty of Science and Technology > Mathematics and Statistics|
|Deposited On:||21 Nov 2008 12:11|
|Last Modified:||26 Jul 2012 15:28|
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