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A note on change point estimation in dose-response trials.

Friede, T. and Miller, F. and Bischoff, W. and Kieser, M. (2001) A note on change point estimation in dose-response trials. Computational Statistics and Data Analysis, 37 (2). pp. 219-232.

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Abstract

An often used model for the shape of a drug's dose–response relationship is the following: the curve increases to a certain dose until a plateau is reached. In this situation, the minimum dose with maximum effect can be seen as a change point in a regression model. We present four estimators for the change point and compare their performance with respect to selection rates and loss function based criteria by extensive simulations. The choice of the loss function depending on the practical situation is discussed. Application of the estimators is illustrated by an example.

Item Type: Article
Journal or Publication Title: Computational Statistics and Data Analysis
Uncontrolled Keywords: Change point estimator ; Dose–response relationship ; Loss function ; LINEX loss
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 19309
Deposited By: ep_ss_importer
Deposited On: 21 Nov 2008 12:11
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19309

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