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Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.

Pendleton, Neil and Payton, Anthony and van den Boogerd, Eelke and Holland, Fiona and Diggle, Peter J. and Rabbitt, Patrick M. A. and Horan, Michael A. and Worthington, Jane and Ollier, William E. R. (2002) Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neuroscience Letters, 324 (1). pp. 74-76. ISSN 0304-3940

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Abstract

There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

Item Type: Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: Apolipoprotein E ; Intelligence ; Genetics ; Aged
Subjects: Q Science > QA Mathematics
Departments: Faculty of Health and Medicine > Medicine
VC's Office
ID Code: 19281
Deposited By: ep_ss_importer
Deposited On: 20 Nov 2008 09:35
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:27
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19281

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