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Identification and efficacy of longitudinal markers for survival.

Henderson, Robin and Diggle, Peter J. and Dobson, Angela (2002) Identification and efficacy of longitudinal markers for survival. Biostatistics, 3 (1). pp. 33-50. ISSN 1468-4357

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Abstract

Methods for the combined analysis of survival time and longitudinal biomarker data have been developed in recent years, with most emphasis on modelling and estimation. This paper focuses on the use of longitudinal marker trajectories as individual-level surrogates for survival. A score test for association which requires only standard methods for implementation is derived for the initial identification of candidate biomarkers. Methods for assessing efficacy of markers are discussed and a measure contrasting conditional and marginal distibutions is proposed. An application using prothrombin index as biomarker for survival of liver cirrhosis patients is included.

Item Type: Article
Journal or Publication Title: Biostatistics
Uncontrolled Keywords: Explained variation ; Joint modelling ; Residual lifetime distribution ; Score test ; Surrogates
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
Faculty of Health and Medicine > Medicine
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ID Code: 19272
Deposited By: ep_ss_importer
Deposited On: 19 Nov 2008 14:55
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:27
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19272

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