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The evolution of lithium therapy.

Johnson, F. N. (1992) The evolution of lithium therapy. Journal of Psychopharmacology, 6 (2). pp. 325-329.

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Abstract

The evolution of lithium therapy for the treatment of mania and depression, from its discovery to the present day, is described. Early problems with toxicity have been overcome and lithium is now established as a safe medication, provided serum levels are monitored. The mechanism of action of lithium is not yet known, but biochemical models are beginning to be put forward. Lower doses of lithium than were previously used are now recommended. Treatment with intermittent doses of lithium (every second day) seems to reduce side effects, while maintaining clinical efficacy. Lithium has recently been used in combination with other medications. Augmentation of unsuccessful antidepressant treatment with lithium may produce an antidepressant effect within a short time. Withdrawal from lithium therapy usually results in a relapse. Lithium treatment is also used outside psychiatry. Other potential clinical applications for lithium therapy are discussed.

Item Type: Article
Journal or Publication Title: Journal of Psychopharmacology
Uncontrolled Keywords: lithium • mania • depression • toxicity • lithium augmentation • withdrawal
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 19098
Deposited By: ep_ss_importer
Deposited On: 30 Oct 2008 09:54
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:26
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/19098

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