Shaunak, Sandip and O’Sullivan, Erin and Blunt, Staira and Lawden, Mark and Crawford, Trevor J. and Henderson, Leslie and Kennard, Christopher (1999) Remembered saccades with variable delay in Parkinson’s disease. Movement Disorders, 14 (1). pp. 80-86. ISSN 0885-3185Full text not available from this repository.
The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.
|Journal or Publication Title:||Movement Disorders|
|Uncontrolled Keywords:||Parkinson's disease ; Remembered saccades ; Basal ganglia ; Dorsolateral prefrontal cortex ; Spatial working memory|
|Subjects:||B Philosophy. Psychology. Religion > BF Psychology|
|Departments:||Faculty of Science and Technology > Psychology|
|Deposited On:||06 Nov 2008 09:01|
|Last Modified:||26 Jul 2012 15:23|
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