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IR microspectroscopy: potential applications in cervical cancer screening.

Walsh, Michael J. and German, Matthew J. and Singh, Maneesh and Pollock, Hubert M. and Hammiche, Azzedine and Kyrgiou, Maria and Stringfellow, Helen F. and Paraskevaidis, Evangelos and Martin-Hirsch, Pierre L. and Martin, Francis L. (2007) IR microspectroscopy: potential applications in cervical cancer screening. Cancer Letters, 246 (1-2). pp. 1-11. ISSN 0304-3835

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Abstract

Screening exfoliative cytology for early dysplastic cells reduces incidence and mortality from squamous carcinoma of the cervix. In the developed world, screening programmes have adopted a 3–5 years recall system. In its absence, cervical cancer would be the second most common female cancer in these regions; instead, it is currently eleventh. However, there exist a number of limitations to the smear test even given the removal of contaminants using liquid-based cytology. It is prohibitively expensive, labour-intensive and subject to inaccuracies that give rise to significant numbers of false negatives. There remains a need for novel approaches to allow efficient and objective interrogation of exfoliative cytology. Methods that variously exploit infrared (IR) microspectroscopy are one possibility. Using IR microspectroscopy, an integrated ‘biochemical-cell fingerprint’ of the lipid, protein and carbohydrate composition of a biomolecular entity may be derived in the form of a spectrum via vibrational transitions of individual chemical bonds. Powerful statistical approaches (e.g. principal component analysis) now facilitate the interrogation of large amounts of spectroscopic data to allow the extraction of what may be small but extremely significant biomarker differences between disease-free and pre-malignant or malignant samples. An increasing wealth of literature points to the ability of IR microspectroscopy to allow the segregation of cells based on their disease status. We review the current evidence supporting its diagnostic potential in cancer biology.

Item Type: Article
Journal or Publication Title: Cancer Letters
Uncontrolled Keywords: Cervical cancer ; Cytological screening ; IR microspectroscopy ; Principal component analysis ; False negatives ; Papanicolaou smear
Subjects: Q Science > QC Physics
Departments: Faculty of Health and Medicine > Health Research
Faculty of Science and Technology > Physics
Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine
ID Code: 18635
Deposited By: ep_ss_importer
Deposited On: 30 Oct 2008 16:34
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:19
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/18635

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