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Non-contact micro-cantilevers detect photothermally induced vibrations that can segregate different categories of exfoliative cervical cytology.

Hammiche, Azzedine and Walsh, Michael J. and Pollock, Hubert M. and Martin-Hirsch, Pierre L. and Martin, Francis L. (2007) Non-contact micro-cantilevers detect photothermally induced vibrations that can segregate different categories of exfoliative cervical cytology. Journal of Biochemical and Biophysical Methods, 70 (4). pp. 675-677. ISSN 0165-022X

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Abstract

We implemented a non-contact photo-thermo-mechanical recording method whereby a silicon nitride atomic force microscopy cantilever is placed several micrometer above the surface of samples. Samples were illuminated with infrared (IR) radiation after which, cantilever mechanical vibrations were optically sensed. Following spectrometric acquisition and Fourier transformation, true IR absorption spectra were obtained. With multivariate analysis, segregation between different categories of exfoliative cervical cytology was obtained. This approach points towards the implementation of a novel near-field system that allows IR spectral analysis without probe contamination.

Item Type: Article
Journal or Publication Title: Journal of Biochemical and Biophysical Methods
Uncontrolled Keywords: Atomic force microscopy cantilever ; Cantilever mechanical vibrations ; IR spectral analysis ; Near-field ; Non-contact ; Photo-thermo-mechanical
Subjects: Q Science > QC Physics
Departments: Faculty of Science and Technology > Physics
Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine
ID Code: 18632
Deposited By: ep_ss_importer
Deposited On: 31 Oct 2008 09:08
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 15:19
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/18632

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