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Spatial clustering of amyotrophic lateral sclerosis in Finland at place of birth and place of death.

Sabel, C. E. and Boyle, P. J. and Löytönen, M. and Gatrell, Anthony C. and Jokelainen, M. and Flowerdew, R. and Maasilta, P. (2003) Spatial clustering of amyotrophic lateral sclerosis in Finland at place of birth and place of death. American Journal of Epidemiology, 157 (10). pp. 898-905. ISSN 1476-6256

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Abstract

Previous evidence for spatial clustering of amyotrophic lateral sclerosis is inconclusive. Studies that have identified apparent clusters have often been based on a small number of cases, which means the results may have occurred by chance processes. Also, most studies have used the geographic location at the time of death as the basis for cluster detection, rather than exploring clusters at other points in the life cycle. In this study, the authors examine 1,000 cases of amyotrophic lateral sclerosis distributed throughout Finland who died between June 1985 and December 1995. Using a spatial-scan statistic, the authors examine whether there are significant clusters of the disease at both time of birth and time of death. Two significant, neighboring clusters were identified in southeast and south-central Finland at the time of death. A single significant cluster was identified in southeast Finland at the time of birth, closely matching one of the clusters identified at the time of death. These results are based on a large sample of cases, and they provide convincing evidence of spatial clustering of this condition. The results demonstrate also that, if the cluster analysis is conducted at different stages of the cases’ life cycle, different conclusions about where potential risk factors may exist might result.

Item Type: Article
Journal or Publication Title: American Journal of Epidemiology
Uncontrolled Keywords: amyotrophic lateral sclerosis ; cluster analysis ; geography
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Health Research
Faculty of Arts & Social Sciences
Faculty of Health and Medicine
ID Code: 13351
Deposited By: Mr Richard Ingham
Deposited On: 17 Sep 2008 10:29
Refereed?: Yes
Published?: Published
Last Modified: 18 Sep 2013 16:10
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/13351

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